CLINICAL CHEMISTRY (Organ Function Tests, Laboratory Investigations and Inborn Metabolic Diseases)

CLINICAL CHEMISTRY 

(Organ Function Tests, Laboratory Investigations and Inborn Metabolic Diseases)

Contents

Part 1: Organ Function Tests 1-82

1. Renal Function Tests .................................................................................................................... 3

2. Liver Function Tests ....................................................................................................................... 15

3. Gastric Function Tests .................................................................................................................... 36

4. Thyroid Function Tests .................................................................................................................. 47

5. Adrenocortical Function Tests ...................................................................................................... 60

6. Pancreatic Function Tests .............................................................................................................. 72

Part 2: Laboratory Investigations 83-262

7. Hyperglycaemia .............................................................................................................................. 85

8. Hypoglycaemia ................................................................................................................................ 96

9. Hypercalcaemia ............................................................................................................................. 106

10. Hypocalcaemia .............................................................................................................................. 118

11. Hypercortisolism ........................................................................................................................... 125

12. Hypocortisolism ............................................................................................................................ 132

13. Hyperlipoproteinaemias (Hyperlipidaemias) ......................................................................... 139

14. Jaundice .......................................................................................................................................... 149

15. Neonatal Jaundice ......................................................................................................................... 159

16. Hyperthyroidism ........................................................................................................................... 171

17. Hypothyroidism ............................................................................................................................ 182

18. Malabsorption Syndrome ............................................................................................................ 191

19. Obesity ............................................................................................................................................ 204

20. Polyuria ........................................................................................................................................... 212

21. Haemolytic Transfusion Reaction ............................................................................................. 218

22. Haemolytic Anaemia .................................................................................................................... 227

23. Iron Deficiency Anaemia ............................................................................................................ 240

24. Macrocytic Megaloblastic Anaemia .......................................................................................... 248

Part 3: Miscellaneous 263-290

25. Enzymes and Isoenzymes in Clinical Medicine ..................................................................... 265

26. Oncogenic Markers (Tumour Markers) .................................................................................... 281

Part 4: Inborn Metabolic Diseases (Inborn Errors of Metabolism) 291-376

27. Inborn Metabolic Diseases (Inborn Errors of Metabolism) ................................................. 293

A. Disorders of Carbohydrate Metabolism .............................................................................. 295

B. Amino Acid Metabolic Disorders ......................................................................................... 327

C. Disorders of Lipid Metabolism ............................................................................................. 358

D. Inborn Errors of Defective DNA Repair and Purines/Pyrimidine Metabolism ........... 365

References ............................................................................................................. 377

Index ...................................................................................................................... 379

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 The ABC of CBC Complet Blood Count Book

Contents

1. Introduction and Significance of CBC 1

2. Red Blood Cells 6

2. A. Red blood cells 6

2. B. Hemoglobin 8

2. C. Reticulocyte 12

2. D. Hematocrit -packed cell volume (PCV) 14

2. E. Mean corpuscular volume 16

2. F. Mean corpuscular hemoglobin 18

2. G. Mean corpuscular hemoglobin concentration (MCHC) 18

2. H. Red cell distribution width (RDW) 19

3. RBCs on Peripheral Smear 23

3. A. RBCs on peripheral smear 24

3. B. Hemoparasite 32

4. White Blood Cells 41

4. A. WBC count 41

4. B. Polymorphs 46

4. C. Eosinophils 52

4. D. Basophils 53

4. E. Monocytes 54

4. F. Lymphocytes 55

5. Platelets 59

5. A. Platelet count 59

5. B. Disorders of platelets 64

5. C. Mean platelet volume (MPV) 66

5. D. Platelet distribution width (PDW) 67

5. E. Plateletcrit (PCT) 68

5. F. Immature platelet fraction (IPF) 68

6. Manual v/s Automation in Hematology 70

7. General Principle of Histogram Generation and Interpretation 82

8. Histograms 87

9. Scattergram 127

10. Case Studies 131

11. Quality Control 162

Bibliography 171

Index 173

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LAB Notes Guide to LAB & DIAGNOSTIC TESTS Book

LAB Notes Guide to LAB & DIAGNOSTIC TESTS

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 100 Cases in Clinical Pathology Book

Hematology in Practice

Hematology in Practice Book

PART I  BASIC HEMATOLOGY PRINCIPLES

1-      Introduction to Hematology and Basic Laboratory Practices

2-      From Hematopoiesis to the Complete Blood Count

3-      Red Blood Cell Production, Function, and Relevant Red Cell Morphology 

4-      Hemoglobin Function and Principles of Hemolysis

PART II RED CELL DISORDERS

5-      The Microcytic Anemias

6-      The Macrocytic Anemias

7-      Normochromic Anemias, Biochemical and Membrane Disorders, and Miscellaneous Red Cell Disorders

8-      The Normochromic Anemias Due to Hemoglobinopathies

PART III WHITE CELL DISORDERS

9-      Leukopoiesis and Leukopoietic Function

10-   Abnormalities of White Cells: Quantitative,Qualitative, and the Lipid Storage Diseases

11-   Acute Leukemias

12-   Chronic Myeloproliferative Disorders

13-   Lymphoproliferative Disorders and Related Plasma Cell Disorders

14-   The Myelodysplastic Syndromes

PART IV HEMOSTASIS AND DISORDERS OF COAGULATION

15-   Overview of Hemostasis and Platelet Physiology

16-   Quantitative and Qualitative Platelet Disorders

17-   Defects of Plasma Clotting Factors

18-   Fibrinogen, Thrombin, and the Fibrinolytic System  

19-   Introduction to Thrombosis and Anticoagulant Therapy

PART V LABORATORY PROCEDURES

20-   Basic Procedures in a Hematology Laboratory

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The Short Textbook of Medical Microbiology

The Short Textbook of Medical Microbiology

(Including Parasitology)

Clinical Chemistry - Principles, Techniques, Correlations

 

Clinical Chemistry - Principles, Techniques, Correlations Book

 Contents

Part (1) Basic Principles and Practice of Clinical Chemistry 

 

1-Basic Principles and Practices

2-Laboratory Safety and Regulations

3-Method Evaluation

4-Lean Six Sigma Methodology for Quality Improvement in the Clinical Chemistry Laboratory

5-Analytic Techniques

6-Chromatography and Mass Spectrometry

7-Principles of Clinical Chemistry Automation

8-Immunochemical Techniques

9-Molecular Theory and Techniques

10-Point-of-Care Testing

Part (2) Clinical Correlations and Analytic Procedures

11-Amino Acids and Proteins

12-Nonprotein Nitrogen Compounds

13-Enzymes

14-Carbohydrates 

15-Lipids and Lipoproteins 

16-Electrolytes 

17-Blood Gases, pH, and Buffer Systems

18-Trace and Toxic Elements

19-Porphyrins and Hemoglobin 

 Part (3) Assessment of Organ System Functions

20-Hypothalamic and Pituitary Function

21-Adrenal Function

22-Gonadal Function

23-The Thyroid Gland 

24-Calcium Homeostasis and Hormonal Regulation

25-Liver Function

26 Laboratory Markers of Cardiac Damage and Function

27-Renal Function

28-Pancreatic Function and Gastrointestinal Function

29-Body Fluid Analysis

Part (4) Specialty Areas of Clinical Chemistry

30-Therapeutic Drug Monitoring

31-Toxicology

32-Circulating Tumor Markers: Basic Concepts and Clinical Applications

33-Nutrition Assessment

34-Clinical Chemistry and the Geriatric Patient

35-Clinical Chemistry and the Pediatric Patient 

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