Postgraduate Haematology Book
EDITED BY
A Victor Hoffbrand MA, DM, FRCP, FRCPath,
FRCP (Edin), DSc, FMedSci
Emeritus Professor of Haematology, University College London, London, UK
Douglas R Higgs MD, FRCP, FRS
Professor of Molecular Haematology & Director, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
David M Keeling BSc, MD, FRCP, FRCPath
Consultant Haematologist, Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals, Oxford, UK
Atul B Mehta MA, MD, FRCP, FRCPath
Consultant Haematologist, Lysosomal Storage Disorders Unit, Department of Haematology, Royal Free Hospital, London, UK
Seventh Edition
Contents
Contributor list, vii
Preface to the seventh edition, x
Preface to the first edition, xi
1 Stem cells and haemopoiesis, 1
Emma de Pater, Elaine Dzierzak
2 Erythropoiesis, 11
Douglas R Higgs, Noemi Roy, Deborah Hay ́
3 Iron metabolism, iron deficiency and disorders of haem synthesis, 21
Clara Camaschella, A Victor Hoffbrand, Chaim Hershko
4 Iron overload, 40
Clara Camaschella, A Victor Hoffbrand, Maria Domenica Cappellini
5 Megaloblastic anaemia, 53
A Victor Hoffbrand
6 Haemoglobin and the inherited disorders of globin synthesis, 72
Swee Lay Thein, David Rees
7 Sickle cell disease, 98
Anne Marsh, Elliott P Vichinsky
8 Hereditary disorders of the red cell membrane and disorders of red cell metabolism, 114
Paola Bianchi, Narla Mohandas
9 Acquired haemolytic anaemias, 138
Modupe O Elebute, Rachel Kesse-Adu
10 Inherited aplastic anaemia/bone marrow failure syndromes, 156
Inderjeet S Dokal
11 Acquired aplastic anaemia and paroxysmal
nocturnal haemoglobinuria, 174
Judith CW Marsh, Austin G Kulasekararaj, Neal S Young, Peter Hillmen
12 Red cell immunohaematology, 195
Geoff Daniels, Marcela Contreras, Shubha Allard
13 Clinical blood transfusion, 214
Shubha Allard, Marcela Contreras
14 Phagocytes, 246
John Mascarenhas, Marina Kremyanskaya, Ronald Hoffman
15 Lysosomal storage disorders, 270
Atul B Mehta, Derralynn A Hughes
16 Normal lymphocytes and non-neoplastic
lymphocyte disorders, 278
Paul Moss, Mark Drayson
17 The spleen, 303
Paul Moss
18 The molecular basis of haematological
malignancies, 314
Niccolo Bolli, George Vassiliou
19 Laboratory diagnosis of haematological
neoplasms, 332
Torsten Haferlach, Barbara J Bain
20 Acute myeloid leukaemia, 352
Alan K Burnett, David Grimwade
21 Adult acute lymphoblastic Llukaemia, 371
Clare J Rowntree, Adele K Fielding
22 Childhood acute lymphoblastic leukaemia, 384
Ajay Vora
23 Supportive care in the management of leukaemia, 399
Eliza Gil, Vanya Gant, Panagiotis Kottaridis
24 Chronic myeloid leukaemia, 419
David TO Yeung, Timothy P Hughes
25 The myelodysplastic syndromes, 438
Kavita Raj, Ghulam J Mufti
26 Myeloproliferative neoplasms, 474
Peter J Campbell, Claire Harrison,
Anthony R Green
27 Chronic lymphocytic leukaemia and other chronic
B-cell disorders, 500
Emili Montserrat, Peter Hillmen
28 T-cell lymphoproliferative disorders, 524
Pier Luigi Zinzani, Alessandro Broccoli
29 Multiple myeloma, 537
Jesus San-Miguel, Joan Blad ́ e ́
30 Amyloidosis, 562
Simon DJ Gibbs, Philip N Hawkins
31 The classification of lymphomas: updating the WHO
classification, 575
Elias Campo, Stefano A Pileri
32 Hodgkin lymphoma, 601
Piers Blombery, David Linch
33 Non-Hodgkin lymphoma: low grade, 614
William Townsend, Robert Marcus
34 Non-Hodgkin lymphoma: high grade, 631
Jessica Okosun, Kate Cwynarski
35 Stem cell transplantation, 651
Charles Craddock, Ronjon Chakraverty
36 Normal haemostasis, 676
Keith Gomez, John H McVey
37 The vascular function of platelets, 699
Stephen P Watson, Neil V Morgan, Paul Harrison
38 Haemophilia and Von Willebrand disease, 715
Michael A Laffan, K John Pasi
39 Rare inherited coagulation disorders, 733
Flora Peyvandi, Marzia Menegatti
40 Acquired coagulation disorders, 743
Peter W Collins, Jecko Thachil, Cheng-Hock Toh
41 Congenital platelet disorders, 761
Maurizio Margaglione, Paul RJ Ames
42 Primary immune thrombocytopenia, 773
Drew Provan, Adrian C Newland
43 Thrombotic thrombocytopenic purpura and
haemolytic–uraemic syndrome (congenital and
acquired), 783
Pier Mannuccio Mannucci, Flora Peyvandi,
Roberta Palla
44 Heritable thrombophilia, 795
Trevor Baglin, David Keeling
45 Acquired venous thrombosis, 809
Beverley J Hunt, Henry G Watson
46 Antithrombotic agents, 820
Trevor Baglin, David Keeling
47 Management of venous thromboembolism, 830
Trevor Baglin, David Keeling
48 Haematological aspects of systemic disease, 838
A Victor Hoffbrand, Atul B Mehta
49 Haematological aspects of tropical diseases, 854
Imelda Bates, Ivy Ekem
50 Neonatal haematology, 870
Irene Roberts, Subarna Chakravorty
51 WHO Classification: Tumours of the
Haematopoietic and Lymphoid Tissues (2008), 885
